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Blood Diseases and Resources Research

Published on AidPage by IDILOGIC on Jun 24, 2005

Examples of funded projects...

(1) An individual research grant to define the latent therapeutic value of epsilon-globin gene reactivation in adults with disorders in beta-globin expression. The research comprises a crucial step in evaluating the promise of developmentally silenced globin genes for individuals with beta-thalassemia and sickle cell anemia. (2) A multi-project grant dealing with abnormalities in the regulation of coagulation and thrombosis which play a major role in the pathogenesis of many heart, lung, and blood diseases. This project integrates the research efforts of a number of independent investigators to explore the molecular basis for selected disorders of coagulation and thrombosis and the role of hemostatic balance in vascular disease pathogenesis. (3) A grant for a Specialized Center of Research (SCOR) in Hematopoietic Stem Cell Biology. The focus is to increase our understanding of hematopoietic differentiation with the ultimate goal of improving the therapy of patients with hematological, immunological, and genetic diseases. (4) A Comprehensive Sickle Cell Center Grant that integrates clinical, translational and basic research, thereby fostering multidisciplinary collaborations directed toward the goal of finding effective therapy and ultimately a cure for sickle cell disease. (5) An Individual National Research Service Award to use in utero gene delivery to target highly proliferative hematopoietic stem cells in the fetal liver of a murine model of beta thalassemia. The fellow will train under the guidance of an accomplished mentor and will develop research skills in the important area of in utero gene transfer strategies for transduction of hematopoiet stem cells and treatment of genetic disorders of the hematopoietic system that cause ongoing morbidity and mortality in children. (6) A Small Business Innovative Research Grant to develop a rapid, accurate, cost-effective screening test to detect a broad array of bacterial contaminants in stored human red blood cells. The successful development of this technology will improve the availability and safety of the human blood supply and will have broad potential for bacterial detection applications in human diagnostic, food testing, environmental testing and other research uses.

About this section

This section indicates the different types of projects which have been funded in the past. Only projects funded under Project Grants or Direct Payments for Specified Use should be listed here. The examples give potential applicants an idea of the types of projects that may be accepted for funding. The agency should list at least five examples of the most recently funded projects.